Me2 - Classics in Synthesis
 
© Brendan Burkett
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Me2 - Classics in Synthesis

brendo1704
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The chemotherapy medication, Taxol (Paclitaxel), was originally isolated from the bark of the Pacific Yew Tree in 1971.  Approved for clinical use in 1993, isolation of the Paclitaxel from the natural source for this purpose was not considered a feasible way to sustain production of the drug.  By the early 1990s, the race was well on to synthesise the molecule by chemical means and dozens of academic groups were working on the problem.  The first complete synthesis appeared in 1994, just a week before a second (even though the second was accepted for publication first), and others soon followed.  The album art described here shows four key academic leaders who worked on the synthesis of paclitaxel in the early-mid 90's: K.C. Nicolaou, Sam Danishefsky, Robert Holton and Paul Wender (Right to left) - classic stuff, just like the Joshua Tree is a classic album.  Double homage!

 

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© Brendan Burkett
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From the album:

At The Joshua Tee

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