Lots of potential there for interesting "Night Two" tweaks. They are even playing 4 nights in Milan in October, and it would be a travesty to have four identical shows to what they've done thus far.
I enjoy the first half of the show more than the second half. If I could wave a magic wand, I'd make some big changes to the second part, and some small tweaks to the first part.
For the first part of the show.:
While "I Will Follow" is always great live, they have played it a lot in recent tours (sometimes swapping ElectricCo or Out of Control, which they could do this time as well). To fit with the SoE theme, a mind-blowing choice out of left field would be "Another Time Another Place" instead. Or, to really get the crowd going, play "11 O'Clock Tick Tock" before "The Ocean", just like how they used to end their shows in 1981.
I can live without "Beautiful Day" at this point. Instead, make sure to play "Red Flag Day" at every show.
My selfish set list for first part of show:
Love is All We Have Left
Lights of Home
Red Flag Day
Another Time Another Place / 11 O'Clock Tick Tock (alternate them each night)
Raised By Wolves (can still have a Sunday Bloody Sunday intro, to tell the childhood story, but keep it short, and weave it into RBW)
Until the End of the World
For the second part:
I respect the crowd-energizing power of Elevation, Vertigo, and Desire to open the second set, as well as "Pride" to fire up the crowd later, but I am tired of them all, and would make substitutions. Here is a chance to inject some variability into Night One vs. Night Two set lists, to keep things interesting.
I also respect the band's desire to perform their new songs (YTBTAM, GOOYOW, American Soul), but I especially don't care for American Soul, and would lose it (including the political references), replacing it with a more unifying "Please" at that juncture in the show. To maintain SoE content, play "The Showman" (which IMO is better than either Summer of Love or Landlady for a live show, as opposed to on the recording).
I would retain only one slot for the "classic hits", and there they can alternate New Year's Day (full version) and Streets.
I would move "Acrobat" to a more powerful position, right before equally powerful "Love is Blindness" to close out the main set with awesomeness.
Add a couple of surprises that will go over well (the first four slots allow for that), and here's my selfish second part of the show:
Electrical Storm / Magnificent (alternate them each night)
City of Blinding Lights / Vertigo (alternate them each night) (the crowd really seems to go nuts for Vertigo, so keep it for one night per city)
Crumbs from Your Table / Miracle Drug (alternate them each night)
Who's Gonna Ride Your Wild Horses / Heartland (alternate them each night) ["Kite" is another possibility, but I think the other two would work better]
You're the Best Thing About Me (electric version would be better, but if they keep acoustic version, then follow it with The Showman, also acoustic)
Get Out of Your Own Way
New Year's Day (full version) / Where the Streets Have No Name (alternate them each night)
Love is Blindness
Closing with "Love is Blindness" (the live version that we know and love) would be huge.
For the encore:
I would include four songs, starting out with something to rouse the fans, then getting back to SoE, adding "Little Things".
Two Hearts Beat as One / The Fly (alternate them each night)
Love is Bigger Than Anything In Its Way
The Little Things That Give You Away
13 (There is a Light) [this covers the elements of "Song for Someone" already, so no need to do both]
A total of 26 numbers (11 + 11 + 4), 7 of which alternate between Nights One and Two, and with 10 songs from SoE.
The first half would be stable and mostly unchanged from the actual set list, whereas the second part would be totally overhauled, and would have four alternating slots. Fans would appreciate attending both shows of a two-night stand.